The myelodysplastic syndrome-myeloproliferative neoplasms (MDS/MPNs) are defined by a group of heterogeneous hematological malignancies resulting from stem cell−driven clonal growth of pathological hematopoietic progenitors and ineffective hematopoiesis, they are characterized by concomitant myelodysplastic and myeloproliferative signs. Myelodysplastic/myeloproliferative disorders have been considered to have a higher risk of thrombus formation. We report a rare case about a 64 years old Moroccan woman, who experienced renal infarction (RI) associated with pulmonary embolism as a complication of a myelodysplastic/myeloproliferative disorder. The patient complained of acute-onset severe left flank pain, a contrast-enhanced computed tomography (CT) of the chest and abdomen revealed RI by a large wedge-shaped defect in the right kidney with pulmonary embolism. The biological exam showed deep anemia, the bone marrow aspiration found myelodysplasia. the bone biopsy showed signs of myeloproliferative disease. The karyotype was normal, BCR-ABL, JAK2, CALR mutations were absents, and MPL mutation was positive. The International Prognostic Scoring System (IPSS-R) was 0, and the patient was included in the low-risk group. Anticoagulation therapy was initiated with heparin to treat RI and pulmonary embolism. Three months later, pulmonary embolism had resolved without the appearance of additional peripheral infarction. This case emphasizes the need to consider myelodysplastic/myeloproliferative disorders as a cause of infraction renal and pulmonary embolism.
Bendari, Mounia; Bouanani, Nouama; Khalfaoui, Mohamed Amine; Ahnach, Maryam; Laaraj, Aziza; and Doghmi, Kamal
"Renal Infarction and Pulmonary Embolism in Patient with Myelodysplastic/Myeloproliferative Neoplasm Unclassifiable,"
Health Sciences: Vol. 1
, Article 16.
Available at: https://doi.org/10.15342/hs.1.182
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