Melanomas are outstandingly aggressive cancers, still their incidence is increasing. They can occur in the skin as cutaneous melanoma or in the eye as ocular melanoma. Their pathogenesis is generally similar; however, the prognosis of ocular melanoma patients is still poor, due to its special genetic profile and tumor microenvironment. Here we review the similarities and differences between cutaneous and ocular melanoma, with a focus on their prognostic significance, their molecular signature, and their tumor microenvironment, in order to understand the strategies adopted to escape immune response. Gathering and understanding available knowledge of melanomas and their specificities may help to identify the group of patients with the unfavorable prognosis in order to identify more effective treatments.
Badou, Abdallah; SALAH, Nour el imane ISSAM; and ELBELHADJI, Mohamed
"Unveiling similarities and differences between cutaneous and ocular melanomas,"
Health Sciences: Vol. 4
, Article 8.
Available at: https://doi.org/10.56264/2658-865X.1086
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